Implication of Therapeutic Intervention on Putative Oxidative stress markers in Cervical Cancer

Background: The present study was undertaken in patients of carcinoma cervix to evaluate the Implication of chemo radiotherapy on status of oxidative stress biomarker such as protein carbonyl, lipid hydro peroxide and antioxidants defence mechanism of melatonin and total thiol levels. Methodology: Patients were delivered radiotherapy by external beam radiotherapy (EBRT) followed by brachytherapy. All patients were given chemotherapy in the form of injection cisplatin. Blood samples were collected from patients as well as control before treatment and within 24 hours and six weeks after chemo radiotherapy. Newly diagnosed women with cervical cancer [N=192], 30-65 years of age and agematched clinically healthy women [N=192] were included in this study. Result &conclusion: The mean LOOH and PC levels in all three groups of cases were comparatively higher than controls. Further, the mean LOOH and PC levels increased in cases after the chemo-radiotherapy as compared to pre chemo-radiotherapy., P<0.001) .Study also found that the mean Melatonin level and total thiol level in all three groups of cases lowered comparatively than controls. Further, the mean Melatonin and total thiol in cases decreased after the chemo-radiotherapy as compared to pre chemo-radiotherapy. We suggest that plasma PC, LOOH, PC, Melatonin and T-SH may serve as biomarkers for oxidative stress in patients with gynecological malignancy. A highly structured study with a larger sample size is required to establish the precise role of oxidative stress in pathobiology of cancer. Such oxidative biomarker can be used for diagnosis and prognosis of diseases in future.